Prior to the Silverstone’s poison frog’s official description in 1979 as Ameerega silverstonei, it was known under incorrect names, such as Phyllobates bicolor or Epipedobates silverstonei.

The Silverstone’s poison frog is “Endangered” due to its small, declining, threat-defined range and continuing decline of mature individuals due to illegal harvesting.

The skin of the Silverstone’s poison frog’s lower body and hind limbs is coarsely granular, gradually smoothing out in the skin of the head, forelimbs and ventral surfaces.

The Silverstone’s poison frog is not a migrant.

The Silverstone’s poison frog is known to be distasteful to snakes, but not much more is known of the frog’s predators.

The Silverstone’s poison frog’s hind limbs are moderately long and the toe discs tend to be slightly wider than the finger discs.

To defend against predators, the Silverstone’s poison frog’s skin secretions contain small amounts of pumiliotoxin-A alkaloids that lack great potency.

The Silverstone’s poison frog’s head is generally as wide as the body and is characterized with a sloping and rounded snout.

The Silverstone’s poison frog gains its brightly orange, red, and black colors at 1 year of age to deter potential predators.

The Silverstone’s poison frog is endemic to the Cordillera Azul mountain range on the eastern side of the high Andes, Huánuco Region in Peru and can be found at elevations from 1,200-1,800 m. above sea level.